| Course Unit Code | 040-0611/01 |
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| Number of ECTS Credits Allocated | 3 ECTS credits |
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| Type of Course Unit * | Choice-compulsory type B |
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| Level of Course Unit * | First Cycle |
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| Year of Study * | Second Year |
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| Semester when the Course Unit is delivered | Summer Semester |
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| Mode of Delivery | Face-to-face |
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| Language of Instruction | Czech |
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| Prerequisites and Co-Requisites | Course succeeds to compulsory courses of previous semester |
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| Name of Lecturer(s) | Personal ID | Name |
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| RAS03 | Ing. Pavel Raška, Ph.D. |
| KLO067 | doc. Ing. et Ing. Karel Klouda, CSc., Ph.D.,MBA |
| ROU0016 | Ing. Petra Roupcová, Ph.D. |
| Summary |
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| The course introduces students into toxicology. They will be acquainted with a group of substances called poisons, gates of poisons entering the organism, possibilities of their processing and modification by the organism, as well as with factors influencing the effect of poisons on the organism. The study will provide an overview of the most important toxic substances that are used in the chemical industry or are products of industrial production. Special attention will be paid to toxic products of combustion processes. |
| Learning Outcomes of the Course Unit |
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The aim of the subject is to acquaint students with the basic principles of toxicology as a scientific discipline. Based on these general principles, they will deepen their knowledge of toxicology of chemical substances, which are frequently processed during processes chemical production or are products of chemical industry.
At the end of the course student should be able to use basic toxicological terms. The study provides an overview of toxic chemicals properties that affect their absorption and transformation within the body. At the same time, he will know the routes of exposure and the mechanisms of toxic action of the most common industrial chemicals. Student will be able to apply the acquired knowledge for the purpose of risk assessment when working with toxic chemicals.
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| Course Contents |
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1. Definition of the subject toxicology, classification of poisons, relationship between the structure of the substance and its toxicity, toxicity evaluation, factors affecting the toxic effect, entry of substances into the body, distribution and mechanisms of action of poisons,
2. Interaction of toxins with the cell, biotransformation and its phases, exposure, toxic substances in the environment and work environment, ecotoxicology,
3. Effects of poisons on organism and organ toxicity - hematotoxic, hepatotoxic, immunotoxic and neurotoxic substances, mutagenic and carcinogenic substances, addictive substances,
4. toxicity of combustion products,
5. Toxicity of raw materials, intermediates, products and wastes of selected chemical productions (inorganic and organic production),
6. Toxicity of industrial gases (chlorine, ammonia, hydrogen),
7. Petrochemistry, toxicity of oil processing product,
8. Chemistry of phosphorus, phosphates and organophosphates of nerve agent,
9. Division of pesticides according to the efficiency of the segment, focus on ecotoxicity,
10. Organic solvents, examples, their risks in application including toxicity,
11. Metals and metal compounds, influence of ionic form on toxicity,
12. Natural toxins with a focus on mycotoxins,
13. Toxicity of nanoparticles with a focus on nanoparticles specifically produced such as graphene, graphene oxide, fullerene, titanium and zinc oxides and the like
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| Recommended or Required Reading |
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| Required Reading: |
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| KUBÁTOVÁ Hana. Průmyslová toxikologie a životní prostředí. Ostrava: Sdružení požárního a bezpečnostního inženýrství, 2018, ISBN 978-80-7385-210-8 |
| KUBÁTOVÁ Hana. Průmyslová toxikologie a životní prostředí. Ostrava: Sdružení požárního a bezpečnostního inženýrství, 2018, ISBN 978-80-7385-210-8 |
| Recommended Reading: |
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LINHART Igor. Toxikologie: Interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. 2. vydání, Praha: VŠCHT v Praze, 2014, ISBN 978-80-7080-877-1
HORÁK Josef, LINHART Igor, KLUSOŇ Petr. Úvod do toxikologie a ekologie pro chemiky. Praha: VŠCHT v Praze, 2004, ISBN 978-80-7080-548-0
GILBERT Steven G. A small dose of toxicology: The Health effect of Common Chemicals. 2nd issue, Seattle: Healthy World Press, 2012, ISBN 978-0-9833378-3-6
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LINHART Igor. Toxikologie: Interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. 2. vydání, Praha: VŠCHT v Praze, 2014, ISBN 978-80-7080-877-1
HORÁK Josef, LINHART Igor, KLUSOŇ Petr. Úvod do toxikologie a ekologie pro chemiky. Praha: VŠCHT v Praze, 2004, ISBN 978-80-7080-548-0
GILBERT Steven G. A small dose of toxicology: The Health effect of Common Chemicals. 2nd issue, Seattle: Healthy World Press, 2012, ISBN 978-0-9833378-3-6
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| Planned learning activities and teaching methods |
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| Lectures, Tutorials |
| Assesment methods and criteria |
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| Task Title | Task Type | Maximum Number of Points
(Act. for Subtasks) | Minimum Number of Points for Task Passing |
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| Credit and Examination | Credit and Examination | 100 (100) | 51 |
| Credit | Credit | 30 | 16 |
| Examination | Examination | 70 | 35 |