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Biocybernetics

* Exchange students do not have to consider this information when selecting suitable courses for an exchange stay.

Course Unit Code450-4031/03
Number of ECTS Credits Allocated4 ECTS credits
Type of Course Unit *Choice-compulsory type B
Level of Course Unit *Second Cycle
Year of Study *Second Year
Semester when the Course Unit is deliveredSummer Semester
Mode of DeliveryFace-to-face
Language of InstructionCzech
Prerequisites and Co-Requisites Course succeeds to compulsory courses of previous semester
Name of Lecturer(s)Personal IDName
KUB631Ing. Jan Kubíček, Ph.D.
VON0045Ing. Jaroslav Vondrák, Ph.D.
Summary
The aim of this object is study principle of genesis, transfer, processing and retention information in vital systems. As well as modeling and simulation of biological systems. Their study of control method on physiological and pathological terms.
The basis forms a cell, biological membrans, biothermodynamic and biophysical chemistry. The study of biological systems features is orientaited on neurophysiologie, neurological, respiratory, locomotive and vascular systems, heart action, genetical information, sensoric systems and compensation of organ functions.

Learning Outcomes of the Course Unit
The student aquired during this course information about the origin of genesis, transformation , evaluation and presevation of information in live systems. As well as modeling and simulation of biological systems. Their study of control method on physiological and pathological terms.
The object with its elignment fits into branch of measurements and control techniques in biomedicine. The aquiered knowledge and skill creates the basic knowledge of biomedicine engineering.
Course Contents
Lectures:
1. Physiological principles.
2. System definition, basic division, basic concepts, feedback, system description, mathematical apparatus.
3. Modeling of biological systems, modeling procedure, Models of static systems, models of dynamic systems, stochastic models of biological systems, basic attributes of systems.
4. Human organism as a system - basic properties of the organism, principles of homeostatic control, control mechanisms, stimuli, structure of the biological system, receptors, homeostatic regulation, thermoregulation
5. Biological membranes. Structure and Functions. Chemical potentials. Conditions of equilibrium in heterogeneous systems. Membrane ion channels. Transporter ion transfer systems via membrane.
6. Neurophysiology - nervous system. Transmission and processing of information in biological systems. The nervous, hormonal and humoral level of their management.
7. Nervous System Structure of the nervous system, possibilities of control at individual levels. Central nervous system. Nerve fiber, replacement scheme, and propellant propagation equation.
8. Heart. Heart activity and importance of control mechanisms under load. The vascular system. The importance of the bloodstream for circulation, the possibilities and the importance of its regulation.
9. Heart Rate Control, Blood Pressure Stabilization
10. Breathing system. Control of the respiratory system. Function of the lung and its regulation in extreme conditions. Breath regulation
11. Motion system. The link between electrical irritation and the mechanical response of the muscle cell. Reflections.
12. Water regulation in the organism, regulation of glycemia, pharmacokinetics
13. Replacement of organ functions. Replacement and support of the function of the internal organs. Replacement of kidney, heart and lung function.
14. Stimulators external and implantable.

Laboratory Exercises:
1. Introduction to the theory of ordinary differential equations: ODR I., II. order and their systems, general and particular solutions, Cauchy task and Laplace transformation.
2. The solution of ordinary differential equations in Simulink. Numerical solvers of differential equations in MATLAB environment.
3. Analytical solution and simulation of population models.
4. Pharmacokinetics: one compartment and two compartment model of drug passage.
5. Analysis and simulation of heart rate dependence on physical load.
6. Modeling of kidney function in stabilizing blood pressure.
7. Pulse compartment: model of gas concentration in alveoli and other tissues.
8. Gastric acidity control model.
9. Model of enzyme reaction and membrane potential.
10. Model Baroreflex.
11. Pulse model of blood circulation.
12. Model of glycemic control.
13. Modeling of skeletal muscle contraction.
14. Fundamentals of PDE and their application in biomedical modeling.
Recommended or Required Reading
Required Reading:
[1] Biomedical modeling and simulation on a pc: a workbench. S.l.: Springer, 2012. ISBN 9781461391654.
[2] MEURS, Willem van. Modeling and simulation in biomedical engineering: applications in cardiorespiratory physiology. 1. New York: McGraw-Hill, c2011. ISBN 978-0071714457.
[3] CHRISTOPOULOS, Arthur. Biomedical applications of computer modeling. Boca Raton: CRC Press, c2001. Pharmacology & toxicology (Boca Raton, Fla.). ISBN 9780849301001.
[4] KITTNAR, Otomar a Mikuláš MLČEK. Atlas fyziologických regulací: 329 schémat. Praha: Grada, 2009, 316 s. ISBN 978-80-247-2722-6.
[1] Biomedical modeling and simulation on a pc: a workbench. S.l.: Springer, 2012. ISBN 9781461391654.
[2] MEURS, Willem van. Modeling and simulation in biomedical engineering: applications in cardiorespiratory physiology. 1. New York: McGraw-Hill, c2011. ISBN 978-0071714457.
[3] CHRISTOPOULOS, Arthur. Biomedical applications of computer modeling. Boca Raton: CRC Press, c2001. Pharmacology & toxicology (Boca Raton, Fla.). ISBN 9780849301001.
[4] KITTNAR, Otomar a Mikuláš MLČEK. Atlas fyziologických regulací: 329 schémat. Praha: Grada, 2009, 316 s. ISBN 978-80-247-2722-6.


Recommended Reading:
Tiefenbach,P: Biocybernetics,Sylabus on WWW pages of department,2002.
Penhaker,M: Biocybernetics,Sylabus on WWW pages of department,2002.
Samson Wright: Klinická fyziologie Praha 1987.
Stefan Silbernagl, Agamemnom Despopoulos: Atlas fyziologie člověka. Praha 1984.
Wiliam F. Canong: Přehled lékařské fyziologie. Praha 1976.
Hrazdíra, I.: Biofyzika. Praha, Avicenum 1990.
Nečas, O.: Biologie. Praha, Avicenum 1982.
Dvořák - Maršík - Andrej: Biotermodynamika. Praha, Akademia, 1985.
Babloyantz, A.: Molecules, dynamics and life, J.Wiley, New York, 1986.

Talbot, S.a.: Systems physiology, J.Wiley, New York 1973.
Tiefenbach,P: Biokybernetika, Sylaby na WWW stránkách katedry, 2002,
Penhaker,M: Biokybernetika, Sylaby na WWW stránkách katedry, 2002,
Samson Wright: Klinická fyziologie Praha 1987.
Stefan Silbernagl, Agamemnom Despopoulos: Atlas fyziologie člověka. Praha 1984.
Wiliam F. Canong: Přehled lékařské fyziologie. Praha 1976.
Hrazdíra, I.: Biofyzika. Praha, Avicenum 1990.
Nečas, O.: Biologie. Praha, Avicenum 1982.
Dvořák - Maršík - Andrej: Biotermodynamika. Praha, Akademia, 1985.
Babloyantz, A.: Molecules, dynamics and life, J.Wiley, New York, 1986.

Talbot, S.a.: Systems physiology, J.Wiley, New York 1973.
Planned learning activities and teaching methods
Lectures, Individual consultations, Tutorials, Other activities
Assesment methods and criteria
Task TitleTask TypeMaximum Number of Points
(Act. for Subtasks)
Minimum Number of Points for Task Passing
Graded creditGraded credit100 (100)51
        Semestrální projektSemestral project40 21
        PísemkaWritten test60 31