| Course Unit Code | 617-2024/01 |
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| Number of ECTS Credits Allocated | 4 ECTS credits |
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| Type of Course Unit * | Choice-compulsory type B |
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| Level of Course Unit * | First Cycle |
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| Year of Study * | Second Year |
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| Semester when the Course Unit is delivered | Winter Semester |
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| Mode of Delivery | Face-to-face |
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| Language of Instruction | Czech |
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| Prerequisites and Co-Requisites | Course succeeds to compulsory courses of previous semester |
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| Name of Lecturer(s) | Personal ID | Name |
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| PAV57 | Ing. Jiří Pavlovský, Ph.D. |
| Summary |
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| The subject introduces students to the harmful with effects of chemicals and chemical products for humans (inorganic and organic compounds), the forms of entry of these substances in the body and more detailed metabolism. The subject also focuses on some areas of biochemistry, organic chemistry and biology in relation to toxicology, including first aid in case of involvement with these substances. Part of this subject is devoted to actions which take place in the human body, detailed procedures for removal of toxic substances, their effect on mutation, degeneration, carcinogenity, reproduction, mutagenity, as well as the influence of toxicity on the brain, liver, heart and other organs, etc., which breaks down toxic substances, including acute toxicity tests. Part of the subject is closely oriented on a more detailed interpretation on field that is devoted to molds and the associated toxic effects, including issues related to toxic mushrooms, drugs, medications and eventually warfare substances, including toxicology of plants. Further the subject introduces students to the applicable laws and associated regulations and regulations from the field of chemicals and chemical products, namely the existing bylaws Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (Text with EEA relevance) and the Law No. 350/2011 Coll., the law on waste, accidents, narcotics and psychotropic substances, etc. Another form are information on the utilization the application of knowledge in chemistry, eventually in other fields, what mean keeping records of chemicals, work and handling with these agents, provided first aid, safety issues, work with chemicals, etc. |
| Learning Outcomes of the Course Unit |
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| Course objective is submit complete information about the harmful and toxic effects of substances (organic and inorganic), basic concepts of the toxicity, teratogenity, mutagenity, etc. Subject matter is also focused on the toxicity of fungi, plants, animals, drugs, eventually chemical weapons. Aspects of conversion of toxic substances are explained as in the human’s body with the individual processes. Part of course is also the legal site and toxicology valid norms, regulations, laws and regulations by the EU. Special attention is devoted to issue of ecotoxicology and tests according to OECD. |
| Course Contents |
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1. Introduction to toxicology, its structure and content. Poisons and other pollutants. Poisons in the history. Theory of toxicity. Routes of entry of substances into the body. Overview of the effects of poisons in the body. Acute and chronic effects of poisons in the body. General principles of treatment of poisoning.
2. The mechanism of effect of toxic substances, factors influencing the effects of toxic substances. Interaction of toxic substances in the body. Metabolism and disposal of toxins in the body, first aid for acute poisoning, the treatment of chronic poisoning. Preventive protection against exposure to toxic and harmful substances.
3. Biology and Biochemistry in relation to the toxicology of chemicals, the existing legislation relating to toxic and harmful to health substances, hygiene norms. Legislation Law: Corrigendum to Regulation (EC) No. 1272/2008 of the European Parlament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006 (OJ L 353, 31.12.2008), Law No. 350/2011 Coll.
4. Degeneration, teratogenity, mutagenity of toxic substances,
5. Law No. 65/2017 Coll. Classification and coding of toxicological properties and hazards of chemical substances and preparations (Law No. 350/2011 Coll.- H, P verdicts, eventually R, S sentences, etc.).
6. Toxicity of selected elements and inorganic compounds.
7. Toxicity of selected elements and inorganic compounds.
8. Toxicity of selected elements and inorganic compounds.
9. Toxicity of selected organic compounds.
10. Toxicity of selected organic compounds.
11. Toxicity of selected organic compounds. Ecotoxicology.
12. Chemical Ecotoxicology, OECD tests, toxicity of the living organisms (animals and plants), toxicity of alkaloids, molds, fungi, drugs, toxic effects from the industrial processing and toxicity of these manufactured products.
13. Toxicity of products - products for home and industrial utilization, eventually chemical weapons. |
| Recommended or Required Reading |
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| Required Reading: |
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MURRAY, L., M. LITTLE, O. PASCU and K. A. HOGGETT. Toxicology Handbook 3rd Edition. Published by Churchill Livingstone Australia, 2015. ISBN 9780729542241.
HARBISON, R. D., M. M. BOURGEOIS and G. T. JOHNSON. Hamilton and Hardy's Industrial Toxicology, 6th Edition. John Wiley & Sons, Inc., 2015. ISBN 978-0-470-92973-5. |
LINHART, I. Toxikologie. Praha: VŠCHT Praha, 2014. ISBN 978-80-7080-877-1.
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| Recommended Reading: |
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| DERELANKO, M. J. and C. S. AULETTA. Handbook of Toxicology, Third Edition. CRC Press, 2014. ISBN 9781439890134. |
| TICHÝ, M. Toxikologie pro chemiky. Praha: Karolinum, dotisk 1. vyd., 2002. ISBN 80-7184-625-2. |
| Planned learning activities and teaching methods |
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| Lectures, Tutorials, Experimental work in labs, Other activities |
| Assesment methods and criteria |
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| Task Title | Task Type | Maximum Number of Points
(Act. for Subtasks) | Minimum Number of Points for Task Passing |
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| Credit and Examination | Credit and Examination | 100 (100) | 51 |
| Credit | Credit | 45 | 17 |
| Examination | Examination | 55 | 34 |