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Basics of toxicology

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Course Unit Code617-2071/01
Number of ECTS Credits Allocated2 ECTS credits
Type of Course Unit *Compulsory
Level of Course Unit *First Cycle
Year of Study *Second Year
Semester when the Course Unit is deliveredWinter Semester
Mode of DeliveryFace-to-face
Language of InstructionCzech
Prerequisites and Co-Requisites Course succeeds to compulsory courses of previous semester
Name of Lecturer(s)Personal IDName
PAV57Ing. Jiří Pavlovský, Ph.D.
Summary
The course "Basics of toxicology" introduces students to the harmful toxic effects of chemicals (inorganic and organic), including methods of entry of these substances into the human body and their more detailed metabolism (biotransformation), including procedures of degradation (excretion) of toxic substances (xenobiotics), description toxicodynamic and toxicokinetic concepts, explanation of other concepts such as efficiency, dose, distribution, the effect of time (acute, chronic effects), absorption, etc. Part of the course is devoted to effect in the human body, the effect of toxic substances on mutation, carcinogenicity, reproduction, mutagenicity, as well as the effect of the toxicity of harmful substances on the function of individual organs in the human body in which toxic substances are eliminated or intoxication is observed. Furthermore, the course acquaints students with applicable laws and associated regulations and decrees in the field of chemical substances and chemical preparations, determining of the classification of substances or mixtures according to CLP 1272/2008/EC, current GHS regulation, labelling and packaging of substances and mixtures, Law No. 61/2014 Coll., on chemical substances and chemical mixtures and on the change of certain laws (Chemical law). Another form is information on the use of knowledge of toxicology in the field of chemistry, or in other fields, i.e. keeping records of chemicals, job description and handling of these substances, providing 1. aid with poisoning, safety issues with chemicals and laboratory safety.
Learning Outcomes of the Course Unit
The aim of the course is submitting complete information about the harmful and toxic effects of substances (organic and inorganic), basic concepts of the toxicity, teratogenicity, mutagenicity, etc. Aspects of conversion of toxic substances are explained as in the human’s body with the individual processes. Part of course is also the legal site and toxicology valid norms, regulations, laws and regulations by the EU.
Course Contents
1. Introduction to toxicology (history), its structure and content. Explanation of credit requirements (completion of the course). Toxicology division. Poisons and other pollutants. Poisons in the history. Theory of toxicity.
2. Routes of entry of substances into the human body (absorption, biotransformation, distribution process). Overview of the effects of poisons in the body. Acute and chronic effects of poisons in the body. General principles of treatment of poisoning. Toxicology versus other technical fields.
3. Explanation of important basic concepts in toxicology. The mechanism of effect of toxic substances, factors influencing the effects of toxic substances (including membrane entry). Interaction of toxic substances in the body.
4. Metabolism and disposal of toxins in the human body, first aid for acute poisoning, the treatment of chronic poisoning. Preventive protection against exposure to toxic and harmful substances.
5. Teratogenicity, mutagenicity, carcinogenicity of toxic substances, explanation of the organism-xenobiotic relationship.
6. The influence of the environment on toxicity, external influences, determination of toxicity for unknown substances. Influence of nanosubstances on toxicity (perspectives-advantages and disadvantages).
7. Valid legislation relating to toxic and harmful to health substances. Legislation Law: Corrigendum to Regulation (EC) No. 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures, regulation GHS, Law No. 61/2014 Coll.
8. Classification and coding of toxicological properties and hazards of chemical substances and preparations. (H, P sentences, signal words, etc.).
9. Toxicity of selected elements and inorganic compounds, part 1.
10. Toxicity of selected elements and inorganic compounds, part 2.
11. Toxicity of selected elements and inorganic compounds, part 3.
12. Toxicity of selected organic compounds, part 1.
13. Toxicity of selected organic compounds, part 2.
14. Toxicity of selected organic compounds, part 3.
Recommended or Required Reading
Required Reading:
Hodgson, E., Levi P.E.: A Textbook of Modern Toxicology. Elsevier Sci. Publ., New York, Amsterdam, London, 1987.
Timbrell, J.A.: Introduction to Toxicology. The 2nd Edition. Taylor and Francis, London, 1994.
Tichý, M.: Toxikologie pro chemiky, Karolinum UK Praha, 1998, 90 s.
Marhold J.: Přehled průmyslové toxikologie.
Hodgson, E., Levi P.E.: A Textbook of Modern Toxicology. Elsevier Sci. Publ., New York, Amsterdam, London, 1987.
Timbrell, J.A.: Introduction to Toxicology. The 2nd Edition. Taylor and Francis, London, 1994.
Recommended Reading:
Murray, L., Daly, F., Little, M., Cadogan, M.: Toxicology Handbook, Kindle Edition, Publisher: Churchill Livingstone Australia, 2010.

Matrka, M., Rustek, V.: Průmyslová toxikologie, VŠCHT Pardubice, 1991, 157 s.
Zákon č. 61/2014 Sb. o chemických látkách a chemických směsích a o změně některých zákonů (chemický zákon).
Murray, L., Daly, F., Little, M., Cadogan, M.: Toxicology Handbook, Kindle Edition, Publisher: Churchill Livingstone Australia, 2010.
Planned learning activities and teaching methods
Lectures
Assesment methods and criteria
Task TitleTask TypeMaximum Number of Points
(Act. for Subtasks)
Minimum Number of Points for Task Passing
ExaminationExamination100 51