Computational Genomics

Type of study	Doctoral
Language of instruction	English
Code	460-6028/02
Abbreviation	VG
Course title	Computational Genomics
Credits	10
Coordinating department	Department of Computer Science
Course coordinator	doc. MUDr. František Mrázek, Ph.D.

Osnova předmětu

• introduction to genetics, history of the human population
• bond analysis, association analysis
• proposals for association studies
• isolated / mixed populations, population substructure, human structural variations
• statistical techniques for measuring gene expression and evaluating the activity of transcription factors / regulatory molecules
• model organisms and genotypic technologies
• DNA sequence - annotation, identification of polymorphisms
• prediction models
• mapping analysis
• approaches for preparing sequencing libraries
• Checking data quality

Povinná literatura

• Pevsner J. Bioinformatics and Functional Genomics, 3rd Edition (2015), Wiley-Blackwell, Hoboken, New Jersey
• Pierce B.A. Genetics: A Conceptual Approach, 5th Edition (2013) W. H. Freeman and Co., New York
• Cristianini N. Introduction to computational genomics (2012), Cambridge University Press
• Mount D. W. Bioinformatics - Genome and Sequence Analysis, 2nd Edition (2004), Cold Spring Harbor Laboratory Press, New York

Doporučená literatura

• Deonier R.C. et al. Computational Genome Analysis: An Introduction (2010), Springer, New York

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