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Terminated in academic year 2020/2021

Organic Chemistry

Type of study Bachelor
Language of instruction Czech
Code 617-0005/05
Abbreviation CHO
Course title Organic Chemistry
Credits 7
Coordinating department Department of Chemistry
Course coordinator doc. Ing. Petr Pánek, CSc.

Subject syllabus

1. Lecture:
Introduction into the organic chemistry. History of organic chemistry. Bonding properties of carbon (molecular orbitals, sigma and pi bond, bond dissociation energy, polarity of bond, hybridization, effects of electrons). Relation between the structure and the properties of substances. Intermolecular interaction (Van der Waals interaction, interaction of dipole, hydrogen bridges) and their influence on the melting and boiling temperatures and solubility.
Seminary:
Bonding properties of carbon.

2. Lecture:
Principles of stereochemistry of organic compounds. Drawing organic molecules (types of formulas, projection, models, 3D-shape of molecules). Polymerism and isomerism (constitution, geometric, enantiomerism). The conformation of organic compounds.
Seminary:
Structure, formula, model. Inference of molecular formula, rational formula and structural formula. Determination of isomerism type by the concrete compounds.

3. Lecture:
Chemical reactions of organic compounds. Ranking of organic reactions. Homolysis and heterolysis. Electrophilic and nucleophilic agents. Aliphatic and alicyclic hydrocarbons. Nomenclature of saturated hydrocarbons. Radical substitution. Cracking (catalyzed and uncatalyzed) and isomerization. Fischer-Tropsch synthesis. Resources of hydrocarbons and their application.
Seminary:
Nomenclature of organic compounds.

4. Lecture:
Unsaturated hydrocarbons. Radical and ion addition to double bond. Elimination reactions. Resources of unsaturated hydrocarbons and their industrial application.
Seminary:
Nomenclature of organic compounds.

5. Lecture:
Aromatic compounds. Delocalization of  electrons. Electrophilic aromatic substitution (nitration, sulfonation, alcylation, acylation, halogenation) and others reactions. Resources of aromates and their industrial application. Toxicity of polyaromatic compounds.
Seminary:
Nomenclature of organic compounds.

6. Lecture:
Derivatives of hydrocarbons. Derivatives of halogens. Physical properties, toxicity and application. Synthesis and important reactions.
Seminary:
Nomenclature of organic compounds.

7. Lecture:
Derivatives of nitrogen (nitrocompounds, amines, diazonium salts, azocompounds). Physical properties, toxicity and application. Synthesis and important reactions.
Laboratory:Preparing of jodoform.

8. Lecture:
Derivatives of sulfure (thioalcohols and thiophenols, sulphides, sulfonic acids). Physical properties and application. Synthesis and important reactions. Detergents.
Laboratory:
Preparing of 4-nitroaniline.

9. Lecture:
Derivatives of oxygen. Alcohols and phenols. Ethers. Physical properties, toxicity and application. Synthesis and important reactions.
Laboratory:
Preparing of fumaric acid.

10. Lecture:
Carbonyl compounds (aldehydes and ketones). Physical properties, toxicity and application. Synthesis and important reactions. Organometallics. Reactivity, toxicity and application. Grignard reagents and their reactions.
Laboratory:
Preparing of acetylsalicyclic acid.

11. Lecture:
Carboxylic acids. Physical properties and application. Synthesis and important reactions (acidity versus structure, neutralization, esterification, decarboxylation).
Laboratory:
Preparing of ethyl formiate.

12. Lecture:
Carboxylic acids derivatives. Halogenkyseliny. Hydroxykyseliny. Oxo carboxylic acids. Amino-acids. Physical properties and application. Synthesis and important reactions.
Laboratory:
Preparing of soda soap.

13. Lecture:
Functional derivatives of carboxylic acids. Acyl halides. Anhydrides. Esters. Amides. Nitriles. Physical properties, toxicity and application. Synthesis and important reactions.
Derivatives of carbonic acid (phosgene, urea and their sulfure analogues).
Seminary: More important reactions of hydrocarbons and derivatives of hydrocarbons.

14. Lecture:
Polymers (classification, structure, properties, basic reactions of polymers preparing, summary of more important technical polymers).
Seminary: Presentation of seminar papers.

Literature

1) John McMurry Organic chemistry . - 6th ed.. - Belmont : Thomson Brooks/Cole, 2004. pp. 1176, ISBN 0-534-38999-6

Advised literature

1) Solomons, T.W.G.,Fryhle C.B: Organic Chemistry. John Wiley & Sons,Inc. 2003 ISBN 0-471-41799-8