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Terminated in academic year 2020/2021

Toxicology

Type of study Follow-up Master
Language of instruction Czech
Code 617-3004/01
Abbreviation Tox
Course title Toxicology
Credits 4
Coordinating department Department of Chemistry
Course coordinator prof. Ing. Petr Praus, Ph.D.

Subject syllabus

1. Introduction to toxicology, its structure and content. Poisons and other pollutants. Poisons in the history. Theory of toxicity. Routes of entry of substances into the body. Overview of the effects of poisons in the body. Acute and chronic effects of poisons in the body. General principles of treatment of poisoning.
2. The mechanism of effect of toxic substances, factors influencing the effects of toxic substances. Interaction of toxic substances in the body. Metabolism and disposal of toxins in the body, first aid for acute poisoning, the treatment of chronic poisoning. Preventive protection against exposure to toxic and harmful substances.
3. Biology and Biochemistry in relation to the toxicology of chemicals, the existing legislation relating to toxic and harmful to health substances, hygiene norms. Legislation Law: Corrigendum to Regulation (EC) No. 1272/2008 of the European Parlament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006 (OJ L 353, 31.12.2008), Law No. 345/2005 Coll.
4. Degeneration, teratogenity, mutagenity of toxic substances,
5. Decree No. 362/2004 Coll. Classification and coding of toxicological properties and hazards of chemical substances and preparations. (H, P verdicts, eventually R, S sentences, etc.).
6. Toxicity of selected elements and inorganic compounds.
7. Toxicity of selected elements and inorganic compounds.
8. Toxicity of selected elements and inorganic compounds.
9. Toxicity of selected organic compounds.
10. Toxicity of selected organic compounds.
11. Toxicity of selected organic compounds. Ecotoxicology.
12. Chemical Ecotoxicology, OECD tests, toxicity of the living organisms (animals and plants), toxicity of alkaloids, molds, fungi, drugs, toxic effects from the industrial processing and toxicity of these manufactured products.
13. Toxicity of products - products for home and industrial utilization, eventually chemical weapons.

Literature

[1] Hodgson, E., Levi P.E.: A Textbook of Modern Toxicology. Elsevier Sci. Publ., New York, Amsterdam, London, 1987.
[2] Timbrell, J.A.: Introduction to Toxicology. The 2nd Edition. Taylor and Francis, London, 1994.
[3] http://eur-lex.europa.eu/Result.do?T1=V1&T2=2008&T3=1272&RechType=RECH_naturel&Submit=Search (Corrigendum to Regulation (EC) No. 1272/2008 of the European Parlament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006 (OJ L 353, 31.12.2008)).

Advised literature

[1] Murray, L., Daly, F., Little, M., Cadogan, M.: Toxicology Handbook, Kindle Edition, Publisher: Churchill Livingstone Australia, 2010.
[2] http://toxnet.nlm.nih.gov/