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Molecular biology for nanotechnologists

Type of study Doctoral
Language of instruction Czech
Code 9360-0208/01
Abbreviation MBN
Course title Molecular biology for nanotechnologists
Credits 10
Coordinating department CNT - Nanotechnology Centre
Course coordinator Ing. Gabriela Kratošová, Ph.D.

Subject syllabus

1. Characterization of the course, model organism in molecular biology, molecular level of genetics, characterisation, function, structures.
2. Nirenberg and Matthai experiment, molecular scissors, recombination technologies, PCR and application.
3. Genome sequencing, complete set of genetic information, different genomic approaches.
4. Gene therapy, pros, cons, cancer and tumour therapy, stem cell therapy.
5. Cell transport mechanism and permeability, cell membranes and functions, intracellular transport.
6. Cell signaling, cellular information processing, classification, realization, mechanism. Signaling pathways.
7. Cell cycle, cell cycle phases, cell differentiation process, cell ageing and death. Programmed cell death, apoptosis.
8. Biosensors. Biomolecules detection and signal recognition, surface immobilization of biomolecules, passivation.
9. Nanomedicine: hyperthermia, gene therapy, immunotoxins, drug delivery.

Literature

1. D. S. Goodsell, Bionanotechnology, Lessons from Nature, John Wiley & Sons, Inc. 2004.

Advised literature

1. Challa S. S. R. Kumar Eds., Nanodevices for the Life Sciences, John Wiley & Sons, Inc. 2006.
2. C. M. Niemeyer and C. A. Mirkin Eds., Nanobiotechnology Concepts, Applications and Perspectives, John Wiley & Sons, Inc. 2005.
3. J. Cooper and T. Cass Eds., Biosensors - A Practical Approach, 2nd Ed., Oxford University Press 2004.
4. A. R. Freitas Jr., Nanomedicine, Basic Capabilities, Volume I, Landes Bioscience 1999, <http://www.nanomedicine.com/NMI.html>.