1. KODÍČEK, Milan, Olga VALENTOVÁ a Radovan HYNEK. Biochemie. Chemický pohled na biologický svět. 2. vyd. Praha: VŠCHT, 2018. ISBN 978-80-7592-013-3 .
2. KODÍČEK, Milan, 2004. Biochemické pojmy: výkladový slovník. Praha: Vysoká škola chemicko-technologická. ISBN 978-80-7080-551-0 .
3. ALBERTS, Bruce, [2006]. Základy buněčné biologie: úvod do molekulární biologie buňky. 2. vyd. Ústí nad Labem: Espero. ISBN 80-902-9062-0.
4. NEČAS, Oldřich. Obecná biologie pro lékařské fakulty. Jinočany, 2000. ISBN 80-860-2246-3 .
Basics of biochemistry and cell biology
| Type of study | Bachelor |
|---|---|
| Language of instruction | Czech |
| Code | 9360-0304/01 |
| Abbreviation | ZBBB |
| Course title | Basics of biochemistry and cell biology |
| Credits | 6 |
| Coordinating department | CNT - Nanotechnology Centre |
| Course coordinator | Ing. Sylva Holešová, Ph.D. |
Subject syllabus
1. Introduction to biochemistry
importance of biochemistry; chemical composition of living organisms; organization of living systems; metabolism; examples of the use of biochemical processes
2. Amino acids and peptides
structure and nomenclature; acid-base properties of amino acids; chemical reactions of amino acids; peptides; hormones
3. Proteins
classification of proteins; chemical and spatial structure; non-covalent interactions; properties and functions of proteins; enzymes
4. Lipids
chemical structure and function of lipids; composition of the biological membrane; transport across membranes
5. Nucleic acids
structure of nucleic acids; nucleosides; nucleotides; structure of DNA, RNA; molecular genetics
6. Carbohydrates and polysaccharides
classification, structure; derivatives of carbohydrates
7. Architecture of Cellular Systems and Molecular Self-Assembly
summary of basic differences between (prokaryotes, eukaryotes, archaea) focused on surfaces and compartmentalization; molecular self-assembly as a fundamental structural principle of living systems (viral capsids, bacterial S-layers, lipid chains); utilization of bacterial structures in nanotechnology (S-layer protein matrices for nanostructures)
8. Biomimetics and Biomineralization
mechanisms of biomineralization; how organisms form inorganic nanostructures; modern functional materials inspired by natural systems.
9. Cellular Interface, Membrane Transport, and Nano-Bio Interactions
bionano-interface; mechanism of nanostructure entry into cells (endocytosis, phagocytosis, pinocytosis); formation of the protein corona on the surface of nanomaterials in biological environments
10. Cell Interactions with Metals and Defense Mechanisms
cellular defense mechanisms; efflux pumps; metallothioneins; sequestration; ROS generation; oxidative stress.
11. Cellular Stress, Programmed Cell Death
cell cycle; cellular stress responses to physicochemical stimuli; mechanism of apoptosis vs. necrosis induced by nanomaterials/metals.
12. Fundamentals of Nanomedicine
drug delivery; theranostics and photothermal/photodynamic therapy.
13. Credit Written Test
during the credit week, study progress is verified via a written test, which is part of the scoring evaluation...
importance of biochemistry; chemical composition of living organisms; organization of living systems; metabolism; examples of the use of biochemical processes
2. Amino acids and peptides
structure and nomenclature; acid-base properties of amino acids; chemical reactions of amino acids; peptides; hormones
3. Proteins
classification of proteins; chemical and spatial structure; non-covalent interactions; properties and functions of proteins; enzymes
4. Lipids
chemical structure and function of lipids; composition of the biological membrane; transport across membranes
5. Nucleic acids
structure of nucleic acids; nucleosides; nucleotides; structure of DNA, RNA; molecular genetics
6. Carbohydrates and polysaccharides
classification, structure; derivatives of carbohydrates
7. Architecture of Cellular Systems and Molecular Self-Assembly
summary of basic differences between (prokaryotes, eukaryotes, archaea) focused on surfaces and compartmentalization; molecular self-assembly as a fundamental structural principle of living systems (viral capsids, bacterial S-layers, lipid chains); utilization of bacterial structures in nanotechnology (S-layer protein matrices for nanostructures)
8. Biomimetics and Biomineralization
mechanisms of biomineralization; how organisms form inorganic nanostructures; modern functional materials inspired by natural systems.
9. Cellular Interface, Membrane Transport, and Nano-Bio Interactions
bionano-interface; mechanism of nanostructure entry into cells (endocytosis, phagocytosis, pinocytosis); formation of the protein corona on the surface of nanomaterials in biological environments
10. Cell Interactions with Metals and Defense Mechanisms
cellular defense mechanisms; efflux pumps; metallothioneins; sequestration; ROS generation; oxidative stress.
11. Cellular Stress, Programmed Cell Death
cell cycle; cellular stress responses to physicochemical stimuli; mechanism of apoptosis vs. necrosis induced by nanomaterials/metals.
12. Fundamentals of Nanomedicine
drug delivery; theranostics and photothermal/photodynamic therapy.
13. Credit Written Test
during the credit week, study progress is verified via a written test, which is part of the scoring evaluation...
Literature
Advised literature
1. MURRAY, Robert a kol. Harperova ilustrovaná biochemie. Galén, 2012. ISBN 978-80-7262-907-7 .
2. MCMURRY, John. Organická chemie. Přeložil Jaroslav JONAS. V Brně: VUTIUM; V Praze, 2007. ISBN 978-80-214-3291-8.
3. NOVÁČEK, František. Fytochemické základy botaniky. Vyd. 2., dopl. Olomouc: Fontána, 2008. ISBN 978-80-7336-457-1 .
4. ZÁVODSKÁ, Radka, Denis BRAY a Alexander JOHNSON. Biologie buněk: základy cytologie, bakteriologie, virologie. 2. vyd. Praha: Scientia. Biologie pro gymnázia, 20006. ISBN 80-869-6015-3.
2. MCMURRY, John. Organická chemie. Přeložil Jaroslav JONAS. V Brně: VUTIUM; V Praze, 2007. ISBN 978-80-214-3291-8.
3. NOVÁČEK, František. Fytochemické základy botaniky. Vyd. 2., dopl. Olomouc: Fontána, 2008. ISBN 978-80-7336-457-1 .
4. ZÁVODSKÁ, Radka, Denis BRAY a Alexander JOHNSON. Biologie buněk: základy cytologie, bakteriologie, virologie. 2. vyd. Praha: Scientia. Biologie pro gymnázia, 20006. ISBN 80-869-6015-3.