The first part of the course focuses on the biophysical principles and their technical application. This is essentially a principle of metabolism, extracorporeal circulation, and implemention of technology for hemodialysis solutions, including. water treatment based on reverse osmosis. Also included are special procedures for a higher level disinfection and cleaning procedures. It is clarified the issue of biocompatibility, special methods of sterilization of blood (haemofiltration) and technical principles of hemodialysis instrumentation (blood pumps, flow gear pumps, sensors, etc.).