Biomarkers and Computational proteomics

The course focuses on biomarkers, their validation and verification and their use in biomedicine. Students will be acquainted with methods and tools used in computational biology and proteomics (alignment of sequences and structures, protein structure prediction, protein folding, protein-protein interaction, protein design and modeling). Qualitative and quantitative methods of protein detection, their importance and use in biomedicine will be discussed and the impact of changes on selected diseases and complications discussed. The aim is to help students quickly cope with proteomics, their clinical use and interpretation of proteomic data, and be able to use computational tools to solve problems in their own research. Examples and practical examples of analyzes of relevant data sets and practical use of proteomics and proteome analyzes in biomedicine will be discussed.