| Course Unit Code | 651-2077/01 |
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| Number of ECTS Credits Allocated | 4 ECTS credits |
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| Type of Course Unit * | Compulsory |
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| Level of Course Unit * | First Cycle |
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| Year of Study * | First Year |
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| Semester when the Course Unit is delivered | Summer Semester |
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| Mode of Delivery | Face-to-face |
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| Language of Instruction | Czech |
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| Prerequisites and Co-Requisites | Course succeeds to compulsory courses of previous semester |
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| Name of Lecturer(s) | Personal ID | Name |
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| LES05 | Prof. Mgr. Jana Kukutschová, Ph.D. |
| MOT127 | Mgr. Oldřich Motyka, Ph.D. |
| Summary |
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| Learning Outcomes of the Course Unit |
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| Graduate of the subject is able to define relevant parameters of nanomaterials contributing to their environmental and health risks. Futher, he/she can explain potential transport and exposure routes of nanomaterials, their potential biotransformation and bioaccumulation within their life cycle. Graduate is able to discuss single aspects of air, water and soil pollution and also the topic of occupational safety of nanomaterials and nanomaterials in form of wastes. Furthermore, he/she can generally describe potential adverse effects of exposure of living organisms to nanomaterials on molecular, cellular and organ level. With respect to nanomaterials applications he/she is able to outline possible ethical issues of selected applications and pre-application assessment of nanomaterials and also to describe legislative framework of this topic. |
| Course Contents |
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1. Introduction to the subject: risk definition, risk assessment methods.
2. Hazardous parameters of nanomaterials: Why are they dangerous? Toxicologically relevant parameters of nanomaterials. Differences from the regular toxicology.
3. Occurence of nanomaterials in the environment – their origin and sources. Indoor nanmaterials. Nanomaterials in a workplace – occupational exposure.
4. Environmental fate of nanomaterials, life cycle assessment, nanomaterials release from nano-enabled products. Nanomaterials as wastes.
5. Environmental risks – air, water and soil pollution – case studies.
6. Exposure to nanomaterials – measurement (dosimetry), exposure routes, entrance of nanomaterials into an organism/cells, translocation, biotransformation, bioaccumulation, deposition in single target sites.
7. Interactions of nanomaterials with living organisms on molecular, cellular and organ level. Genotoxic effects, oxidative stress.
8. In vitro toxicity testing of nanomaterials – introdution to nanotoxicology.
9. In vivo, in silico methods of toxicity assessment/prediction of nanomaterials. Trends in nanomaterials toxicity assessment.
10. Selected biomedical, hygienic and environmental applications and their risks – case studies.
11. Ecotoxicity of nanomaterials – impact on organisms from different trophic levels. Impact on autotrophic and heterotrophic organisms, adverse effects on vital functions of plants and animals.
12. Health risks of nanomaterials – impact on tissues, organs, etc.
13. Health risks of nanomaterials – occupational exposure and safety.
14. Ethical aspects of nanomaterials use and current legislation framework for usage and regulation of nanomaterials.
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| Recommended or Required Reading |
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| Required Reading: |
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1. VOGEL, Ulla, ed. Handbook of nanosafety: measurement, exposure and toxicology. London: Elsevier Academic Press, c2014. ISBN 978-0-12-416604-2.
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1. FILIPOVÁ, Zuzana, Jana KUKUTSCHOVÁ a Miroslav MAŠLÁŇ. Rizika nanomateriálů. Olomouc: Univerzita Palackého v Olomouci, 2012, 87 s. Učebnice. ISBN 978-80-244-3201-4.
2. DHAWAN, Alok, Diana ANDERSON a Rishi SHANKER, ed. Nanotoxicology: experimental and computational perspectives. [Cambridge]: Royal Society of Chemistry, [2018]. Issues in toxicology, No. 35. ISBN 978-1-78262-158-4.
3. FAZARRO, Dominick, Walt TRYBULA, Jitendra TATE a Craig HANKS, ed. Nano-safety: what we need to know to protect workers. Berlin: De Gruyter, [2017]. De Gruyter graduate. ISBN 978-3-11-037375-2. |
| Recommended Reading: |
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| 1. WOHLLEBEN, Wendel, Thomas A. J. KUHLBUSCH, Jürgen SCHNEKENBURGER a Claus-Michael LEHR, ed. Safety of nanomaterials along their lifecycle: release, exposure, and human hazards. Boca Raton: CRC Press, Taylor & Francis Group, [2015]. ISBN 978-1-4665-6786-3. |
| 1. SKŘEHOT, Petr a Marcela RUPOVÁ. Nanobezpečnost. Praha: Výzkumný ústav bezpečnosti práce, 2011. ISBN 978-80-86973-89-0. |
| Planned learning activities and teaching methods |
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| Lectures, Individual consultations, Project work |
| Assesment methods and criteria |
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| Task Title | Task Type | Maximum Number of Points
(Act. for Subtasks) | Minimum Number of Points for Task Passing |
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| Examination | Examination | 100 | 51 |