| Course Unit Code | 9360-0128/01 |
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| Number of ECTS Credits Allocated | 2 ECTS credits |
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| Type of Course Unit * | Compulsory |
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| Level of Course Unit * | First Cycle |
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| Year of Study * | Second Year |
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| Semester when the Course Unit is delivered | Winter Semester |
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| Mode of Delivery | Face-to-face |
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| Language of Instruction | Czech |
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| Prerequisites and Co-Requisites | Course succeeds to compulsory courses of previous semester |
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| Name of Lecturer(s) | Personal ID | Name |
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| LAC10 | Ing. Zdenek Lacný |
| Summary |
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| The subject "Basics of Toxicology" serves to familiarize students with basic problems of toxicity of chemical compounds, mechanisms of entry, absorption, distribution, biotransformation and excretion of xenobiotics from the organism. The basic toxicokinetic and toxicodynamic concepts used in the literature are defined. In detail, toxicologically relevant inorganic and organic compounds are discussed. part of the subject is focused on current legislation and basic overview of labor safety rules in chemical laboratory, as well as principles of first aid in intoxication. |
| Learning Outcomes of the Course Unit |
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| Basic knowledge of toxicology. |
| Course Contents |
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1. Fundamentals of toxikology.
2. Basic terms of toxikology and its history.
3. Toxic effect and characteristic of toxic effect.
4. Relationship between dose and effectRoutes of Human Exposure from the Environment
5. Biotransformation
6. Local and Systemic Effects
7. Acute and Chronic Toxicity
8. Uptake toxic substances by organism
9. Harmful Effects of Some Toxic Substances – inorganic compounds
10. Harmful Effects of Some Toxic Substances – organic compounds
11. Chemical Safety Information
12. Environmental Toxicology
13. Hazard and Risk
14. Management of Potentially Toxic Substances |
| Recommended or Required Reading |
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| Required Reading: |
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J.H. Duffus, H.G.J. Worth.: Fundamental Toxicology for Chemists ,The Royal
Society of Chemistry,1996 [ISBN 0854045295]
HODGSON, Ernest. A textbook of modern toxicology. 3rd ed. Hoboken: Wiley, 2004. ISBN 0-471-64677-6. |
Marková.: Základy toxikologie. OU Ostrava, 1998.
Marhold.: Přehled průmyslové toxikologie – Organické látky. Avicenum Praha, 1986.
J.H. Duffus, H.G.J. Worth.: Fundamental Toxicology for Chemists ,The Royal Society of Chemistry,1996, ISBN 0854045295. |
| Recommended Reading: |
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Flanagan R. J.: Fundamentals of Analytical Toxicology, J. Wiley 2007, West Sussex.
DONALDSON, Kenneth a Paul BORM, ed. Particle toxicology. Boca Raton: CRC Press/Taylor & Francis, c2007. ISBN 978-0-8493-5092-4. |
J. Prokeš aj.: Základy toxikologie. Obecná toxikologie a ekotoxikologie. Galén, Praha 2005.
Paleček, Linhart, Horák.:Toxikologie a bezpečnost práce v chemii.VŠCHT Praha, 1996, 80-7080-266-9.
Marhold.: Přehled průmyslové toxikologie – Anorganické látky. Avicenum Praha, 1980, 08-085-80.
Sbírka zákonů ČR. |
| Planned learning activities and teaching methods |
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| Lectures |
| Assesment methods and criteria |
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| Task Title | Task Type | Maximum Number of Points
(Act. for Subtasks) | Minimum Number of Points for Task Passing |
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| Examination | Examination | 100 | 51 |