| Course Unit Code | 546-0158/01 |
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| Number of ECTS Credits Allocated | 4 ECTS credits |
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| Type of Course Unit * | Compulsory |
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| Level of Course Unit * | Second Cycle |
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| Year of Study * | First Year |
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| Semester when the Course Unit is delivered | Summer Semester |
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| Mode of Delivery | Face-to-face |
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| Language of Instruction | Czech |
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| Prerequisites and Co-Requisites | Course succeeds to compulsory courses of previous semester |
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| Name of Lecturer(s) | Personal ID | Name |
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| PER34 | doc. Mgr. Eva Pertile, Ph.D. |
| Summary |
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| The course focuses on the toxic effects of raw materials, intermediates, products and wastes in the industry on humans, especially in relation to environmental and occupational exposures and risks. Attention is also paid to determining the risks to the biosphere arising from human industrial activity. The essence of the course is knowledge about the effects of individual groups of substances on the human body and knowledge about which toxic substances are produced by which industry. An integral part of the course is legislation in the field of chemical safety and prevention. |
| Learning Outcomes of the Course Unit |
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The aim of the course is to acquaint students with the influence of industry on man and his environment.
Knowledge: The student will gain knowledge and acquire terminology in the field of industrial toxicology. They will understand and be able to describe the toxicological effects of selected hazardous substances. They can describe the values of NOEL, LOEL, NOAEL, LOAEL, the principle of their determination. Gain knowledge of current legislation in the protection of health when working with chemicals and preparations.
Skills: The student will know the rules of classification and labelling of hazardous substances and mixtures. Can describe the factors influencing the effects of substances on the human body; be familiar with the legislation of the Czech Republic and the EU in the field of substances and mixtures, protection of public health and safety and health at work. Can describe the principles of risk assessment and health protection when working with substances and mixtures, procedures in accidents related to exposure to substances and mixtures; describe the hazardous properties of important inorganic and organic substances. Can navigate sources of information on the hazardous properties of substances and mixtures, work with materials that provide rules for optimizing operations; draw up operating rules. |
| Course Contents |
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1. Introduction to industrial and environmental toxicology; literature, information sources; definitions, dose-effect relationship, toxicity, substance interactions at different levels; toxicokinetics; bioavailability, etc.
2. Principles of toxicology related to industry and the environment; dose-response; toxicity mechanisms, hazard assessment principles. Hazardous physicochemical properties, their testing. Individual types of toxic effects and possibilities of influencing them.
3. Methods of classification of chemical substances in the Czech Republic and the EU. The current system of classification of substances hazardous to health and the environment and risk assessment system. Safety of chemical products, some internationally monitored groups of chemical substances. Current chemical legislation
4. Introduction to the toxicology of the main classes of industrial and environmental compounds. Testing and evaluation of ecotoxicity and other properties dangerous for the environment, substances and mixtures dangerous for the environment.
5. Origin and types of waste in industrial production. Chemical properties of waste from industrial production. Hazardous substances in waste, hygienic and toxicological aspects of the generation, use and disposal of waste, management of hazardous waste from industrial production.
6. Biocidal substances; insecticides, rodenticides, pesticides. Antibacterial agents. Antibiotics. Antifungals. Virostatics. Protozoal biocides. Cytostatics. Antiseptics. Effects on humans and the environment.
7. Drugs in the environment. Indirect exposure to the human population. Sources of emissions. Ecotoxicology of drugs.
8. Ecotoxically important environmental pollutants (oxides of sulfur, nitrogen, ozone, nitrates, cyanides, PAHs, PCBs, dioxins, other pollutants from industrial production) and their monitoring. Pollutant cycle in the environment.
9. Substances produced by industry and their occurrence in plants. Protective and preventive measures in industrial production. Determination of toxic properties from the literature: toxicological data (LD, LC, NOAEL, LOAEL, etc.), toxicological databases, safety data sheets.
10. Toxicological characteristics of organic compounds, organoelement and organometallic compounds - mechanism of interaction in the organism and the environment, transport and metabolism.
11. Toxicology of industrial raw materials, intermediate products, products and waste pollutants in selected organic technological processes. Toxicologically important organic substances (benzene, asbestos, glycols, vinyl chloride, products of the petrochemical industry, etc.) in the work environment: occurrence, side effects and prevention.
12. Toxicological characteristics of elements, hazardous metals, inorganic compounds in selected technological processes (production of acids, bases, salts, ammonia, fertilizers, etc.). Toxicologically important metals in the work environment: occurrence, side effects and prevention.
13. Pollution by toxic elements from mineral processing: occurrence, side effects and prevention. |
| Recommended or Required Reading |
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| Required Reading: |
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POHANISH, Richard P. a Marshall SITTIG. [i]Sittig's handbook of toxic and hazardous chemicals and carcinogens[/i]. 6th ed. Waltham, MA: William Andrew, c2012. ISBN 978-1-4377-7869-4.
HODGSON, Ernest. [i]A textbook of modern toxicology[/i]. 3rd ed. Hoboken, N.J.: John Wiley, c2004. ISBN 0-471-26508-x.
ROBINSON, Laura a Ian THORN. [i]Toxicology and ecotoxicology in chemical safety assessment[/i]. Malden, MA: Blackwell Pub., 2005. ISBN 978-1-405-11559-9.
WILLIAMS, Phillip L., Robert C. JAMES a Stephen M. ROBERTS. [i]Principles of toxicology: environmental and industrial applications[/i]. 2nd ed. New York: Wiley, 2000. ISBN 0-471-29321-0.
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KUBÁTOVÁ, Hana. Průmyslová toxikologie a životní prostředí. Ostrava: Sdružení požárního a bezpečnostního inženýrství, 2018. Spektrum. ISBN 9788073852108.
LINHART, Igor. Toxikologie: interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. Praha: Vysoká škola chemicko-technologická v Praze, 2014. ISBN 978-80-7080-877-1.
BABIČKA, Luboš. Toxicky významné látky v potravinách. Praha: Potravinářská komora České republiky, Česká technologická platforma pro potraviny, 2017. ISBN 978-80-88019-28-2.
ROBINSON, Laura a Ian THORN. Toxicology and ecotoxicology in chemical safety assessment. Malden, MA: Blackwell Pub., 2005. ISBN 978-1-405-11559-9. |
| Recommended Reading: |
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CARSON, P. A. a C. J. MUMFORD. [i]Hazardous chemicals handbook[/i]. 2nd ed. Boston: Butterworth-Heinemann, 2002. ISBN 0-7506-4888-0.
GREIM, H. a R. SNYDER (Ed.). [i]Toxicology and Risk Assessment: A Com prehensive Introduction[/i]. John Wiley & Sons, Ltd. 2008. ISBN: 978-0-470-86893-5.
MCDERMOTT, Henry J. a Shirley A. NESS. [i]Air monitoring for toxic exposures[/i]. 2nd ed. Hoboken, N.J.: Wiley-Interscience, c2004. ISBN 0-471-45435-4.
GOWDER, Sivakumar, ed. [i]New Insights into Toxicity and Drug Testing[/i]. InTech, 2013. DOI: 10.5772/55886. ISBN 978-953-51-0946-4. |
HORÁK, Josef, Igor LINHART a Petr KLUSOŇ. Úvod do toxikologie a ekologie pro chemiky. Praha: VŠCHT, 2004. ISBN 9788070805480.
MAŠEK, Ivan, Otakar J. MIKA a Miloš ZEMAN. Prevence závažných průmyslových havárií. Brno: Vysoké učení technické v Brně, Fakulta chemická, 2006. ISBN 80-214-3336-1.
MATRKA, Miroslav a Vlastimil RUSEK. Průmyslová toxikologie: úvod do obecné a speciální toxikologie. Pardubice: Univerzita Pardubice, 1994. ISBN 80-85113-85-6.
KEPÁK, František. Průmyslové odpady. Ústí nad Labem: Univerzita Jana Evangelisty Purkyně v Ústí nad Labem, Fakulta životního prostředí, 2010. ISBN 978-80-7414-228-4.
Zákon č. 350/2011 Sb. Zákon o chemických látkách a chemických směsích a o změně některých zákonů, (chemický zákon), ve znění pozdějších předpisů. In: Sbírka zákonů ČR, 2011.
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| Planned learning activities and teaching methods |
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| Lectures, Experimental work in labs, Project work |
| Assesment methods and criteria |
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| Task Title | Task Type | Maximum Number of Points
(Act. for Subtasks) | Minimum Number of Points for Task Passing |
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| Credit and Examination | Credit and Examination | 100 (100) | 51 |
| Credit | Credit | 30 (30) | 15 |
| Semestrální projekt | Semestral project | 30 | 15 |
| Examination | Examination | 70 | 35 |